Peer-reviewed veterinary case report
Fecal S100A12 levels in cats with chronic gut disease
By Kailee A Zornow et al.·Published in Journal of feline medicine and surgery·2023·View original on Semantic Scholar →
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Original publication title: Fecal S100A12 concentrations in cats with chronic enteropathies
- Species:
- cat
Plain-English summary
A group of cats with ongoing gastrointestinal issues for more than three weeks had their fecal samples tested for a substance called S100A12. The results showed that cats with certain types of chronic enteropathy, like inflammatory bowel disease or alimentary lymphoma, had much higher levels of S100A12 compared to healthy cats. This suggests that measuring S100A12 could help veterinarians identify gastrointestinal problems in cats. However, the study found that S100A12 levels did not help distinguish between the different types of chronic enteropathy. More research is needed to see how useful this test could be in diagnosing these conditions.
People also search for: cat diarrhea treatment · cat inflammatory bowel disease symptoms · cat lymphoma diagnosis · cat gastrointestinal problems · S100A12 test for cats
Abstract
Objectives The aim of this study was to compare fecal S100A12 concentrations in cats diagnosed with chronic enteropathy (CE) with healthy control cats. Methods This was a prospective, cross-sectional study. Forty-nine cats that had gastrointestinal signs for >3 weeks and a complete diagnostic work-up, including bloodwork, abdominal ultrasound and upper and/or lower gastrointestinal endoscopic biopsies, were enrolled into the CE group. Nineteen cats from the CE group were diagnosed with inflammatory bowel disease (IBD) or chronic inflammatory enteropathy (CIE) and 30 with alimentary lymphoma (LSA), based on histopathology results and additional testing with immunohistochemistry or molecular clonality testing with PCR if indicated. Nineteen apparently healthy control cats were included in the study. One fecal sample was collected from each cat and S100A12 concentrations were quantified by an analytically validated in-house ELISA. Results Fecal S100A12 concentrations differed between cats with LSA (median 110 ng/g; interquartile range [IQR] 18-548) and control cats (median 4 ng/g; IQR 2-25 [P <0.001]) and between cats with IBD (median 34 ng/g; IQR 15–973) and control cats (P <0.003). S100A12 concentrations in CE cats (median 94 ng/g; IQR 16–548) were statistically significantly higher compared with control cats (P <0.001). The area under the receiver operating characteristic curve (AUROC) to separate healthy cats from CE cats was 0.81 (95% confidence interval [CI] 0.70–0.92) and was statistically significant (P <0.001). The AUROC to separate cats with IBD from cats with LSA was 0.51 (95% CI 0.34–0.68) and was not statistically significant (P = 0.9). Conclusions and relevance Fecal S100A12 concentrations at the time of diagnostic investigation were higher in cats with CIE and LSA than in healthy controls but did not differ between cats with LSA and those with CIE/IBD. This study is an initial step toward evaluating a novel non-invasive marker of feline CIE. Further studies are needed to determine the diagnostic utility of fecal S100A12 concentrations in cats with CE, including comparing cats with IBD/CIE and LSA, and to compare them with cats with extra-gastrointestinal disease.
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Search related cases →Original publication on Semantic Scholar: https://www.semanticscholar.org/paper/36995216