Peer-reviewed veterinary case report
Feline chronic gingivostomatitis diagnosis and treatment using gene
By Soltero-Rivera, Maria et al.·Published in Pathogens (Basel, Switzerland)·2024·Department of Surgical and Radiological Sciences, United States·View original on PubMed →
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Original publication title: Feline Chronic Gingivostomatitis Diagnosis and Treatment through Transcriptomic Insights.
- Species:
- cat
Plain-English summary
A cat with severe mouth inflammation, known as feline chronic gingivostomatitis (FCGS), was studied to find better ways to diagnose and treat this painful condition. The researchers looked at genetic material from the cat's mouth to identify specific markers that could help predict how well different treatments would work. They found that certain enzymes and signaling pathways were linked to the disease and treatment responses. This research suggests that using advanced genetic testing could lead to earlier diagnosis and more effective treatments for cats suffering from FCGS.
People also search for: cat mouth inflammation treatment · feline chronic gingivostomatitis symptoms · cat dental disease diagnosis
Abstract
Feline chronic gingivostomatitis (FCGS) is a debilitating inflammatory oral mucosal disease with a multifactorial etiology. The clinical diagnosis of FCGS is made based on inspection of severe inflammatory lesions and histological confirmation rather than a molecular diagnostic outcome. This gap limits the ability to provide an early diagnosis. In this report, we seek to provide additional diagnostic tools using genomics to aid in providing clinically relevant information. The use of in-depth diagnostic tools, like transcriptomics of diseased tissues, to diagnose FCGS and stratify patients into predictive treatment response groups would dramatically improve both clinical decisions and patient outcomes. In this study, we addressed the gap in diagnostic options using transcriptomic analysis of caudal oral mucosal swab specimens coupled to detailed medical record linkage of FCGS-affected cats undergoing tooth extractions and in some cases administration of mesenchymal stromal cells (MSCs). To better identify markers of disease and potential response to treatment, the transcriptomes of FCGS-afflicted cats were compared to those of healthy cats and those with chronic periodontitis to clearly establish diagnostic biomarker signal transduction connections. Phosphatidylinositol 3-kinase/Ak strain transforming (PI3K/AKT) and stress-activated protein kinases/Jun N-terminal kinase (SAP/JNK) signaling pathways were significantly differentially regulated in FCGS-afflicted cats. Activation of these pathways also differed in the treatment response groups. In conjunction, the enzymes Caspase 4 (CASP4), matrix metalloproteinase-8 (MMP8), and prostaglandin-endoperoxide synthase 2 (PTGS2) were identified as potential biomarkers for the prediction of treatment response outcomes. The observations in the case study support the use of transcriptomics of FCGS patients to contribute to improved molecular diagnostics for the diagnosis and treatment of FCGS.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38535535/