Feline high-grade and large granular lymphocyte alimentary lymphomas treated with COP- or CHOP-based chemotherapy: A multi-centric retrospective study of 57 cases.

Abstract

Specific data regarding outcome of cats with high-grade and large granular lymphocyte alimentary lymphoma (HGAL and LGL, respectively) treated with multi-agent chemotherapy are scarce. The aims of this multi-centric, retrospective study were to describe the outcome of cats with HGAL and LGL treated with COP- or CHOP-based chemotherapy and to identify potential prognostic factors. Cats with a cytological or histological diagnosis of HGAL or LGL lymphoma treated with COP- or CHOP-based protocol as first-line chemotherapy were included. Data regarding diagnosis, staging, treatment and follow-up were collected. Fifty-seven cats treated with CHOP (n&#x2009;=&#x2009;37) or COP (n&#x2009;=&#x2009;20) protocols were included. Complete response (CR), partial response (PR), stable disease (SD) and progressive disease (PD) were observed in 20%, 22%, 36% and 22% of cats, respectively, for an overall response rate of 42%. Median progression-free interval (PFI) was 148&#x2009;days and overall median survival time (OST) was 131&#x2009;days. Cats achieving CR, PR or SD showed significantly longer PFI (p&#x2009;<&#x2009;.01) and OST (p&#x2009;<&#x2009;.015) compared with cats with PD. Other positive prognostic factors in multi-variate analysis were rescue treatment (p&#x2009;<&#x2009;.001) and absence of lymph node involvement (p&#x2009;<&#x2009;.03). Negative prognostic factors were diffuse infiltration of the gastrointestinal tract (p&#x2009;=&#x2009;.035) and infiltration of a non-haematopoietic organ (p&#x2009;<&#x2009;.01).