Peer-reviewed veterinary case report
Cat with kidney cancer causing belly fluid buildup and spread
By Wu, BinXi et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2022·College of Veterinary Medicine, United States·View original on PubMed →
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Original publication title: Feline sarcomatoid renal cell carcinoma with peritoneal carcinomatosis and effusion.
- Species:
- cat
Plain-English summary
A 9-year-old male domestic medium-hair cat with a history of chronic kidney disease started showing signs of not eating and vomiting. An ultrasound showed fluid in the abdomen and a mass near the left kidney. Tests on the fluid and mass revealed cancerous cells, leading to a diagnosis of sarcomatoid renal cell carcinoma, which had spread throughout the abdomen. Unfortunately, the cat did not survive, but researchers were able to establish a cell culture from the tumor for future studies.
People also search for: cat vomiting and not eating · chronic kidney disease in cats · cat kidney cancer treatment
Abstract
A 9-y-old, castrated male, domestic medium-hair cat diagnosed previously with chronic kidney disease developed anorexia and vomiting. Ultrasonography revealed abdominal effusion and a left renal perihilar mass. Cytologic evaluation of the peritoneal fluid and mass identified atypical epithelioid cells suspected to be of renal epithelial or possible mesothelial origin. Immunohistochemical (IHC) evaluation of a formalin-fixed, paraffin-embedded peritoneal fluid cell block indicated both pancytokeratin and vimentin expression in the atypical epithelioid cell population. With scanning electron microscopic evaluation, similar epithelioid cells lacked the cell-surface microvilli expected of mesothelium, supporting an antemortem diagnosis of probable carcinoma. On postmortem examination, the left kidney was effaced by an infiltrative neoplasm with myriad similar nodules throughout the peritoneum. The neoplasm was composed primarily of polygonal-to-spindle-shaped cells with strong vimentin and weak pancytokeratin cytoplasmic immunolabeling. Further IHC characterization with PAX8, CK18, KIT, napsin A, SMA, desmin, CD18, and claudin 5 was performed. Histologic and IHC findings supported a diagnosis of sarcomatoid renal cell carcinoma with peritoneal carcinomatosis. An in vitro cell culture line of neoplastic cells harvested from the primary tumor was successfully established for future research endeavors.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34713776/