Peer-reviewed veterinary case report
Uterine carcinosarcoma with giant cells in a cat
By Murakami, Mami et al.·Published in The Journal of veterinary medical science·2022·Faculty of Applied Biological Sciences, Japan·View original on PubMed →
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Original publication title: Feline uterine carcinosarcoma infiltrated with osteoclast-like giant cells.
- Species:
- cat
Plain-English summary
A 12-year-old female Himalayan cat had surgery to remove a mass in her abdomen, which turned out to be a rare type of uterine cancer called carcinosarcoma. During the examination of the mass, unusual giant cells were found, which are not typically seen in pets. These findings are significant because this type of tumor with these specific cells has not been reported in cats before. Unfortunately, the outcome for this condition is not detailed, but it highlights the need for further research into such rare tumors in animals.
People also search for: cat abdominal mass · Himalayan cat cancer symptoms · uterine tumor in cats · cat surgery recovery · carcinosarcoma in cats
Abstract
A 12-year-old female Himalayan cat underwent an ovariohysterectomy to remove an intra-abdominal mass. Histologic examination using immunohistochemical staining revealed that the mass was comprised of epithelial and mesenchymal components. Within the lesion, multinucleated giant cells (MGCs) were observed diffusely. MGCs were positive for vimentin and Iba-1 and negative for cytokeratin AE1/AE3 and CD204. In addition, MGCs were negative for Ki-67, indicating nonneoplastic cells. Osteoclast-like MGC (OLMGC) phenotype with tartrate-resistant acid phosphatase positivity was also seen. These findings suggested that the uterine tumor was carcinosarcoma with OLMGCs. Uterine tumors in humans, such as leiomyosarcoma and carcinosarcoma, with OLMGC infiltration, are well-known pathologic entities; however, they are rare in animals and to our knowledge, have not been previously reported in cats.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36261364/