Peer-reviewed veterinary case report
Fibroblastic osteosarcoma tumor in Greyhound dog's femur
By Jenkins, Tiffany L et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2018·Department of Veterinary Biosciences, United States·View original on PubMed →
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Original publication title: Fibroblastic osteosarcoma with epithelioid and squamous differentiation in a dog.
- Species:
- dog
Plain-English summary
A 9-year-old spayed female Greyhound was diagnosed with a rare type of bone cancer called fibroblastic osteosarcoma, which was found in her right thigh bone. The tumor was hard and pale, replacing normal bone tissue. After a thorough examination, including an autopsy, the vet confirmed that this was a unique form of osteosarcoma with specific cell types present. Unfortunately, the abstract does not provide information on treatment or outcome, so it's unclear how the dog responded to any interventions.
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Abstract
A fibroblastic osteosarcoma with epithelioid and squamous differentiation in the distal femur of a 9-y-old spayed female Greyhound dog is described. Grossly, the tumor consisted of a pale-white, firm-to-hard mass that replaced the medullary and cortical areas of the distal end of the right femur. Histologically, the mass was composed predominantly of spindle cells admixed with areas of mineralized and non-mineralized osteoid matrix that were surrounded by stellate osteoblasts and scattered multinucleate giant cells, consistent with the diagnosis of a fibroblastic osteosarcoma. In addition, well-demarcated clusters of neoplastic epithelioid cells and foci of squamous differentiation with keratin pearls were present throughout the neoplasm. The spindle cells, epithelioid cells, and areas of squamous differentiation expressed cytoplasmic immunostaining for osteocalcin and osteonectin. The spindle cells and epithelioid cells were also immunopositive for vimentin. Epithelioid cells also expressed occasional cytoplasmic immunostaining for pancytokeratin (PCK) Lu-5, and areas of squamous differentiation were immunoreactive for PCK Lu-5 and high molecular weight CK; these areas were inconsistently immunoreactive for CK 5-6 and immunonegative for low molecular weight CK. Foci of squamous differentiation were not located within blood or lymphatic vessels, given that no immunoreactivity for factor VIII-related antigen was observed around these areas. A thorough autopsy and an evaluation of the medical history excluded a primary carcinoma or other neoplasm elsewhere in the dog. The findings were consistent with a diagnosis of fibroblastic osteosarcoma with epithelioid and squamous differentiation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29629646/