Peer-reviewed veterinary case report
Fibrosarcomas at presumed sites of injection in dogs: characteristics and comparison with non-vaccination site fibrosarcomas and feline post-vaccinal fibrosarcomas.
- Journal:
- Journal of veterinary medicine. A, Physiology, pathology, clinical medicine
- Year:
- 2003
- Authors:
- Vascellari, M et al.
- Affiliation:
- Histopathology Department · Italy
Plain-English summary
This study looked at 15 fibrosarcomas, which are a type of tumor, in dogs that were found at places where injections were given, and compared them to 10 tumors from dogs that were not at injection sites, as well as 20 tumors from cats that developed after vaccinations. The tumors in dogs from injection sites were graded based on their severity, with some being less severe (grade I) and others more severe (grade III). All the tumors showed signs of inflammation around their edges, and some had specific cells that are often seen in these types of tumors. Interestingly, the study found that both dogs and cats could develop similar tumors after injections, suggesting that this is a concern for both species. Overall, the findings indicate that dogs can develop post-injection fibrosarcomas, similar to those seen in cats.
Abstract
Fifteen fibrosarcomas, surgically excised from presumed sites of injection in dogs, and 10 canine fibrosarcomas excised from sites not used for injection were histologically and immunohistochemically compared with 20 feline post-vaccinal fibrosarcomas. Canine fibrosarcomas from presumed injection sites were of grade I (3), of grade II (4) and grade III (8). Two fibrosarcomas from non-injection sites were of grade I, four of grade II and four of grade III. Feline samples were classified as grade I (2), grade II (4) and grade III (14). All fibrosarcomas from presumed injection sites of both species showed lymphocytic inflammatory infiltration located at the tumour periphery, while two canine fibrosarcomas from non-injection sites showed perivascular inflammatory infiltration within the neoplasm. All samples were immunohistochemically examined for vimentin, smooth muscle actin, muscle specific actin and desmin expression. All tumours were positive for vimentin. Ten canine fibrosarcomas from presumed injection sites and all feline samples contained cells consistent with a myofibroblastic immunophenotype. Aluminium deposits were detected in eight canine fibrosarcomas from presumed injection sites and 11 feline post-vaccinal fibrosarcomas by the aurintricarboxylic acid method. The present study identifies distinct similarities between canine fibrosarcomas from presumed injection sites and feline post-vaccinal fibrosarcomas, suggesting the possibility of the development of post-injection sarcomas not only in cats, but also in dogs.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/12887620/