Peer-reviewed veterinary case report
First confirmed Ehrlichia canis infection in a dog in Japan
By Suto, Y et al.·Published in The Veterinary record·2001·Suto Animal Hospital, Japan·View original on PubMed →
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Original publication title: First confirmed canine case of Ehrlichia canis infection in Japan.
- Species:
- dog
Plain-English summary
An 11-year-old castrated Pekingese dog was diagnosed with an Ehrlichia canis infection, which is a type of tick-borne disease. The dog showed signs of anemia and low platelet counts but unfortunately did not improve with treatment using tetracycline and later died from kidney failure. The infection was confirmed after the dog passed away through various tests, including examining the spleen tissue. This case marks the first confirmed instance of this infection in Japan.
People also search for: Pekingese dog kidney failure · Ehrlichia canis symptoms in dogs · dog tick-borne disease treatment
Abstract
An 11-year-old castrated Pekinese dog that had been moved from Indonesia to Japan eight years previously was diagnosed with an Ehrlichia canis infection by haematological characteristics (normocytic anaemia, mild thrombocytopenia and hypergammaglobulinaemia) and serological findings (antibody titre to E canis 1:3,200 or more). The dog did not respond to treatment with tetracycline and died from renal failure. The diagnosis was confirmed postmortem by pathological evaluation and polymerase chain reaction (PCR) followed by sequencing of the 16S rRNA gene. Typical morulae of Ehrlichia were detected in the cytoplasm of macrophages in spleen tissue by immunohistological staining. Ehrlichia-like organisms were also detected in the spleen by electron microscopy. E canis-specific PCR analysis of DNA extracted from the spleen gave a positive signal, and sequence analysis of the fragment revealed that it was identical to part of the 16s rRNA gene of E canis. The dog was the first confirmed clinical case of E canis infection in Japan.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/11467609/