Peer-reviewed veterinary case report
Florfenicol urine levels after oral dose in dogs for UTI treatment
By KuKanich, Kate S et al.·Published in Journal of veterinary pharmacology and therapeutics·2024·Department of Clinical Sciences, United States·View original on PubMed →
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Original publication title: Florfenicol urinary excretion and its potential for treating canine urinary tract infections.
- Species:
- dog
Plain-English summary
A group of dogs, including Beagles and other breeds, were given an oral medication called florfenicol to see if it could help treat urinary tract infections. Most of the dogs took the medication well, although a few showed mild side effects like salivation and head shaking. The amount of florfenicol found in their urine varied by breed, with larger dogs showing higher concentrations that could be effective against infections. The study suggests that florfenicol might need to be given every 6 to 12 hours for it to work properly in dogs with urinary tract infections, but more research is needed to confirm this.
People also search for: dog urinary tract infection treatment · florfenicol for dogs · side effects of florfenicol in dogs
Abstract
The canine urinary excretion of florfenicol was evaluated to explore its potential for treating urinary tract infections. Nine healthy male intact purpose-bred Beagles and four healthy client-owned dogs each received a single oral dose of florfenicol 20 mg/kg (300 mg/mL parenteral solution) with food. All voluntary urinations were collected for 12 h. Although florfenicol is reportedly bitter tasting, 7/9 Beagles and 4/4 client-owned dogs completely ingested the florfenicol and were enrolled; salivation (n = 1) and headshaking (n = 3) were observed. The last measured urine florfenicol concentrations were variable: Beagles (0.23-3.19 mcg/mL), Pug (3.01 mcg/mL) English Setter (21.29 mcg/mL), Greyhound (32.68 mcg/mL), and Standard Poodle (13.00 mcg/mL). Urine half-life was similar for the Beagles and the Pug, 0.75-1.39 h, whereas the half-life was 1.70-1.82 h for the English Setter, Greyhound, and Standard Poodle. Larger breed dogs exceeded 8 mcg/mL florfenicol (wild-type cutoff) in their urine at 12 h, whereas the Beagles and Pug had <8 mcg/mL; it is unclear if this is an individual, breed, or size difference. These data suggest oral florfenicol may need to be administered q6-12h for canine urinary tract infections, but further data are needed (more enrolled dogs, multiple-dose regimens) before considering clinical trials or breed-specific differences.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38420879/