Peer-reviewed veterinary case report
Ki67 test helps grade malignancy in canine lymphoma
By Poggi, A et al.·Published in Veterinary and comparative oncology·2015·Department of Veterinary Science, Italy·View original on PubMed →
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Original publication title: Flow cytometric evaluation of ki67 for the determination of malignancy grade in canine lymphoma.
- Species:
- dog
Plain-English summary
A study looked at how a specific test called the Ki67 index can help determine the severity of lymphoma in dogs. Researchers examined lymph node samples from 90 dogs with lymphoma, finding that those with high-grade lymphoma had much higher Ki67 levels compared to those with low-grade lymphoma. This test was very accurate, correctly identifying high-grade cases almost all the time. The results suggest that using the Ki67 index along with the type of lymphoma can help vets better classify and treat this serious condition in dogs.
People also search for: dog lymphoma treatment · Ki67 index in dogs · high-grade lymphoma symptoms in dogs
Abstract
Ki67 is a nuclear antigen significantly correlated with degree of malignancy in human non-Hodgkin lymphomas. We wanted to assess the ability of flow cytometric evaluation of Ki67 index (Ki67I) in differentiating the grade of malignancy in canine lymphomas. Ki67I was determined on lymph node aspirates of 90 immunophenotyped lymphomas classified according to the updated Kiel classification: 80 high grade (HG, 62 B cell and 18 T cell) and 10 low grade (LG, 3 B cell and 7 T cell) lymphomas. HG lymphomas showed significantly higher Ki67I compared with LG lymphomas (P < 0.0001). A significant difference in HG lymphomas was detected between B- and T-immunophenotypes. Receiver operating characteristic (ROC) curve highlighted a high accuracy of Ki67I in recognizing HG lymphomas [area under the curve (AUC) = 99.4] and a cut-off value of 12.2% was established (sensitivity = 96.3% and specificity = 100%). Thus, we suggest the combination of Ki67I flow cytometric determination and immunophenotype as a reliable tool to classify canine lymphomas.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24341365/