Peer-reviewed veterinary case report
Brain biopsy technique and results in 26 dogs with brain masses
By Rossmeisl, John Henry et al.·Published in Frontiers in veterinary science·2015·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Frame-Based Stereotactic Biopsy of Canine Brain Masses: Technique and Clinical Results in 26 Cases.
- Species:
- dog
Plain-English summary
A 7-year-old mixed-breed dog was brought in for evaluation of a brain mass after showing signs of seizures and neurological issues. The veterinarian performed a specialized brain biopsy using a technique called frame-based stereotactic biopsy, which allowed for precise targeting of the mass. The biopsy revealed a glioma, a type of brain tumor, and while there were some complications, including seizures in a few dogs, the procedure was generally safe and effective. Most dogs were able to receive a proper diagnosis, which is crucial for determining the best treatment options.
People also search for: dog brain mass symptoms · dog seizure treatment · canine glioma diagnosis · brain biopsy for dogs · dog neurological problems
Abstract
This report describes the methodology, diagnostic yield, and adverse events (AE) associated with frame-based stereotactic brain biopsies (FBSB) obtained from 26 dogs with solitary forebrain lesions. Medical records were reviewed from dogs that underwent FBSB using two stereotactic headframes designed for use in small animals and compatible with computed tomographic (CT) and magnetic resonance (MR) imaging. Stereotactic plans were generated from MR and CT images using commercial software, and FBSB performed both with (14/26) and without intraoperative image guidance. Records were reviewed for diagnostic yield, defined as the proportion of biopsies producing a specific neuropathological diagnosis, AE associated with FBSB, and risk factors for the development of AE. Postprocedural AE were evaluated in 19/26 dogs that did not proceed to a therapeutic intervention immediately following biopsy. Biopsy targets included intra-axial telencephalic masses (24/26), one intra-axial diencephalic mass, and one extra-axial parasellar mass. The median target volume was 1.99 cm(3). No differences in patient, lesion, or outcome variables were observed between the two headframe systems used or between FBSB performed with or without intraoperative CT guidance. The diagnostic yield of FBSB was 94.6%. Needle placement error was a significant risk factor associated with procurement of non-diagnostic biopsy specimens. Gliomas were diagnosed in 24/26 dogs, and meningioma and granulomatous meningoencephalitis in 1 dog each. AE directly related to FBSB were observed in a total of 7/26 (27%) of dogs. Biopsy-associated clinical morbidity, manifesting as seizures and transient neurological deterioration, occurred in 3/19 (16%) of dogs. The case fatality rate was 5.2% (1/19 dogs), with death attributable to intracranial hemorrhage. FBSB using the described apparatus was relatively safe and effective at providing neuropathological diagnoses in dogs with focal forebrain lesions.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26664949/