Peer-reviewed veterinary case report
Future investigations in stem cell activation with granulocyte-colony-stimulating factor after myocardial infarction.
- Journal:
- Nature clinical practice. Cardiovascular medicine
- Year:
- 2007
- Authors:
- Ince, Hüseyin & Nienaber, Christoph A
- Affiliation:
- University Hospital Rostock · Germany
Abstract
Experimental data indicate that stem cell mobilization with granulocyte colony-stimulating factor (G-CSF) might have potential as a novel therapeutic strategy for acute myocardial infarction. The prospective beneficial effects of G-CSF can be attributed mainly to a direct action on injured myocardium rather than on differentiation of mobilized bone marrow stem cells into cardiac myocytes. This article reviews the evidence for the potential cardioprotective effects of G-CSF and discusses future investigations regarding pharmacologic stem cell activation and mobilization with G-CSF in the setting of acute myocardial infarction.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17230209/