Peer-reviewed veterinary case report
Dog with rare gamma delta T-cell lymphoma and megaesophagus
By Ortiz, Ana Liza et al.·Published in Veterinary clinical pathology·2015·University of Cambridge Veterinary School Trust, United Kingdom·View original on PubMed →
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Original publication title: Gamma delta T-cell large granular lymphocyte lymphoma in a dog.
- Species:
- dog
Plain-English summary
A 2-year-old female neutered Labrador Retriever was brought in with symptoms including Horner syndrome (drooping eyelid and pupil changes) and megaesophagus (difficulty swallowing), along with a mass in her chest. After tests, she was diagnosed with a type of lymphoma called gamma delta T-cell large granular lymphocyte lymphoma. The vet started her on chemotherapy with several medications, but unfortunately, her condition worsened, and her owners chose to euthanize her 28 days later due to her declining quality of life.
People also search for: Labrador lymphoma symptoms · dog chemotherapy side effects · why is my dog having trouble swallowing
Abstract
A 2-year and 6-month-old female neutered Labrador Retriever with Horner syndrome, megaesophagus, and a mediastinal mass was referred to the Queen Mother Hospital for Animals of the Royal Veterinary College. A large granular lymphocyte (LGL) lymphoma was diagnosed on cytology; flow cytometric analysis revealed a γδ T-cell phenotype (CD3+, CD5+, CD45+, TCRγδ+, CD4-, CD8-, CD34-, CD21-). Chemotherapy was started with a combination of lomustine, vincristine, procarbazine, and prednisolone, followed by bleyomicin. Euthanasia was elected by the owners, due to progressive deterioration and lack of quality of life, 28 days after diagnosis. This is the first cytologic and immunophenotypic characterization of a canine γδ T-cell lymphoma with LGL morphology and probably of mediastinal origin. The role of chemotherapy in delaying the disease progression remains unknown.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25965815/