Peer-reviewed veterinary case report
Puppy with thalamus brain tumor causing seizures
By Uchida, Kazuyuki et al.·Published in The Journal of veterinary medical science·2003·Department of Veterinary Pathology, Japan·View original on PubMed →
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Original publication title: Ganglioglioma in the thalamus of a puppy.
- Species:
- dog
Plain-English summary
A 4-month-old miniature dachshund was brought in for seizure-like symptoms, which led to further investigation. During a necropsy, a 1.5 cm white tumor was found in the thalamus, the part of the brain that helps control movement and sensory information. The tumor was diagnosed as a ganglioglioma, a type of brain tumor made up of nerve cells and supportive cells. Unfortunately, the puppy did not survive, but this case highlights the importance of recognizing neurological signs in young dogs.
People also search for: puppy seizures · miniature dachshund brain tumor · ganglioglioma in dogs · dog seizure treatment options
Abstract
A solitary brain mass of a 4-month-old miniature dachshund showing seizure-like neurological signs was examined histopathologically. At necropsy a white tumor mass, replacing the thalamus, approximately 1.5 cm in diameter, was found. There was cystic space filled with yellowish pale fluid in the central area of the tumor mass. Histopathological examination revealed that the mass consisted of irregularly arranged well-differentiated neuronal and glial cells, and multifocal mineral deposits. The neuronal cells had a large clear nucleus and various amount of Nissl substances in the cytoplasm. Some neural cells were bi-nucleated. Neither mitotic figures nor proliferating cell nuclear antigen (PCNA)-positive nuclei was found in the neuronal cells. Immunostaining for glial fibrillary acidic protein (GFAP) revealed diffuse proliferation of GFAP-positive glial cells and their processes, while these glial cells did not show apparent cellular atypism, mitotic activity, or PCNA-immunoreactivity. Accordingly, the present tumor was diagnosed as ganglioglioma, and hamartomatous histogenesis might be possible.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/12576715/