Peer-reviewed veterinary case report
Dog with stomach B-cell lymphoma and Mott cells diagnosis
By De Zan, Gabrita et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2009·Dipartimento di Sanità, Italy·View original on PubMed →
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Original publication title: Gastric B-cell lymphoma with Mott cell differentiation in a dog.
- Species:
- dog
Plain-English summary
An 8-year-old male crossbreed dog was diagnosed with a type of stomach cancer called gastric B-cell lymphoma after suffering from gastrointestinal issues for six months. Despite surgery and treatments with prednisolone and cimetidine, his condition worsened, leading to his euthanasia. A post-mortem examination revealed multiple tumors in the stomach, spleen, and other organs, indicating that the cancer had spread significantly. Unfortunately, the treatments did not provide the relief needed, and the dog did not recover.
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Abstract
A gastric lymphoid tumor with involvement of regional lymph nodes and spleen was diagnosed in an 8-year-old crossbreed male dog with a 6-month history of gastrointestinal disease. Despite surgical excision and palliative therapy (prednisolone and cimetidine), the dog was euthanatized due to worsening of clinical signs. At necropsy, multiple white, solid, nodular, infiltrative masses were observed in the stomach, duodenum, spleen, liver, and lungs in association with generalized lymph node enlargement. Cytology, histology, histochemistry, immunohistochemistry, and electron microscopy revealed that the neoplastic cell population was composed of B lymphocytes that contained variable amounts of round periodic acid-Schiff-positive cytoplasmic globules consistent with Russell bodies. The tumor most likely represented a variant of B-cell neoplasia with extensive Mott cell differentiation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19737772/