Gastric coinfection with thiopeptide-positivedecreases FOXM1 and pro-inflammatory biomarker expression in a murine model of-induced gastric cancer.

Abstract

infects half of the world population and is the leading cause of gastric cancer. We previously demonstrated that gastric cancer risk is associated with gastric microbiota. Specifically, gastric urease-positiveandhad contrasting effects on-associated gastric pathology and immune responses in germ-free INS-GAS mice. As gastritis progresses to gastric cancer, the oncogenic transcription factorbecomes increasingly expressed. In this study, we evaluated the gastric commensal, certain strains of which produce thiopeptides that directly inhibit FOXM1. Thiopeptide-positivewas isolated from Nicaraguan patient gastric biopsies and inoculated into germ-free INS-GAS mice with. We, therefore, asked whether coinfection withexpressing thiopeptide andwould decrease gastricexpression and pro-inflammatory cytokine mRNA and protein levels. Our study supports the growing literature that specific non-.gastric bacteria affect inflammatory and cancer biomarkers inpathogenesis.