Peer-reviewed veterinary case report
Cat with gastrointestinal tumor lacking KIT and PDGFRA gene mutations
By Fujii, Y et al.·Published in The Journal of small animal practice·2022·Joint Graduate School of Veterinary Sciences, Japan·View original on PubMed →
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Original publication title: Gastrointestinal stromal tumour lacking mutations in the KIT and PDGFRA genes in a cat.
- Species:
- cat
Plain-English summary
A 10-year-old male domestic shorthair cat was diagnosed with a gastrointestinal stromal tumor after showing signs of vomiting and weight loss. The veterinarian tried treating the tumor with tyrosine kinase inhibitors, which are often effective in similar cases, but unfortunately, the cat did not respond to this treatment. Genetic testing showed that the tumor did not have mutations in the KIT and PDGFRA genes, which are often linked to treatment success. This case highlights the need for more research into personalized treatment options for cats with this type of tumor.
People also search for: cat gastrointestinal stromal tumor treatment · why is my cat vomiting · cat weight loss causes
Abstract
Molecular subtyping in gastrointestinal stromal tumours is a useful method for predicting the efficacy of treatment using tyrosine kinase inhibitors in humans. However, owing to the paucity of reports on mutational analyses, the association between genetic mutations and the therapeutic response to tyrosine kinase inhibitors remains unclear in feline gastrointestinal stromal tumours. In this report, we describe the case of a cat with a gastrointestinal stromal tumour which was unresponsive to tyrosine kinase inhibitors. A mutational analysis revealed that the cat lacked mutations in both the KIT and platelet-derived growth factor receptor-alpha (PDGFRA) genes. Our findings are consistent with the fact that KIT/PDGFRA wild-type gastrointestinal stromal tumours are less responsive to tyrosine kinase inhibitors in humans. This signifies the need for further evaluation and possibly individualised treatment for gastrointestinal stromal tumours in cats on the basis of mutational analyses.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34409605/