Peer-reviewed veterinary case report
Gene expressions of canine angiopoietin-1 and -2 in normal tissues and spontaneous tumours.
- Journal:
- Research in veterinary science
- Year:
- 2006
- Authors:
- Kato, Y et al.
- Affiliation:
- Department of Veterinary Medicine · Japan
- Species:
- dog
Abstract
The angiopoietin (Ang) family of proteins are central to the regulation of angiogenesis. The purposes of this study were to determine cDNA sequences of canine Ang-1 and Ang-2 and investigate their expressions in normal tissues and spontaneous tumours. The cDNA sequences of canine Ang-1 and Ang-2 were 1,494 and 1,488 bp, and the deduced amino acid sequences were 497 and 495 residues, respectively. The cDNA sequences of canine Ang-1 and Ang-2 showed high homology with those of the other mammalian species. Canine Ang-1 and Ang-2 mRNA were detectable in all 22 normal tissues and spontaneous tumours. Higher mRNA expression level of canine Ang-2 was demonstrated in mammary simple carcinomas, haemangiosarcoma and hepatocellular carcinoma in comparison with normal tissues.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16545849/