Peer-reviewed veterinary case report
Peripheral swelling in two dogs linked to amlodipine treatment
By Creevy, K E et al.·Published in The Journal of small animal practice·2013·Department of Small Animal Medicine and Surgery, United States·View original on PubMed →
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Original publication title: Generalised peripheral oedema associated with amlodipine therapy in two dogs.
- Species:
- dog
Plain-English summary
A 7-year-old mixed breed dog developed swelling in its legs after starting amlodipine, a medication often used for high blood pressure. Despite thorough testing, no other cause for the swelling was found. The vet stopped the medication, and the swelling improved significantly within three days. In another case, a dog started amlodipine for high blood pressure but developed severe leg swelling that did not improve, leading to the difficult decision of euthanasia. This highlights the importance of monitoring for serious side effects when using common medications like amlodipine in dogs.
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Abstract
This report details two cases of adverse drug reactions to amlodipine. The first case presented with diffuse peripheral oedema and a history of amlodipine therapy. Haematology, clinical chemistry, endocrine testing, thoracic, abdominal and cardiac imaging revealed no cause for oedema. Amlodipine therapy was discontinued and oedema diminished markedly within 72 hours. The second case presented for bilateral retinal detachments secondary to systemic hypertension. Haematology, clinical chemistry, thoracic and abdominal imaging were unremarkable and amlodipine therapy was begun. Within 72 hours, diffuse peripheral oedema developed that was unresponsive to therapy and the dog was euthanised. Veterinarians should be aware of the potential serious adverse events associated with commonly used drugs; severe, diffuse oedema is a possible adverse drug event in dogs treated with amlodipine.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23834642/