Peer-reviewed veterinary case report
Gene linked to bone cancer risk in Leonberger dogs
By Letko, Anna et al.·Published in Genes·2021·Institute of Genetics·View original on PubMed →
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Original publication title: Genome-Wide Analyses for Osteosarcoma in Leonberger Dogs Reveal theGene Locus as a Major Risk Locus.
- Species:
- dog
Plain-English summary
A group of Leonberger dogs, known for their larger size, has been found to have a significant genetic risk for developing osteosarcoma, a common bone cancer in dogs. Researchers studied 273 Leonberger cases, mostly around 8 years old, and identified a specific gene locus on chromosome 11 that is linked to this increased risk. This genetic factor appears to play a crucial role in the likelihood of these dogs developing the disease. Understanding these genetic markers could help in managing and potentially preventing osteosarcoma in at-risk breeds.
People also search for: Leonberger osteosarcoma risk · dog bone cancer genetics · how to prevent osteosarcoma in dogs
Abstract
Dogs represent a unique spontaneous cancer model. Osteosarcoma (OSA) is the most common primary bone tumor in dogs (OMIA 001441-9615), and strongly resembles human forms of OSA. Several large- to giant-sized dog breeds, including the Leonberger, have a greatly increased risk of developing OSA. We performed genome-wide association analysis with high-density imputed SNP genotype data from 273 Leonberger cases with a median age of 8.1 [3.1-13.5] years and 365 controls older than eight years. This analysis revealed significant associations at thegene locus on canine chromosome 11, mirroring previous findings in other dog breeds, such as the greyhound, that also show an elevated risk for OSA. Heritability (h) was determined to be 20.6% (SE = 0.08;-value = 5.7 × 10) based on a breed prevalence of 20%. The 2563 SNPs across the genome accounted for nearly all the hof OSA, with 2183 SNPs of small effect, 316 SNPs of moderate effect, and 64 SNPs of large effect. As with many other cancers it is likely that regulatory, non-coding variants underlie the increased risk for cancer development. Our findings confirm a complex genetic basis of OSA, moderate heritability, and the crucial role of thelocus leading to strong cancer predisposition in dogs. It will ultimately be interesting to study and compare the known genetic loci associated with canine OSA in human OSA.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34946912/