Peer-reviewed veterinary case report
Brain tumor causing ataxia and circling in a Pembroke Welsh corgi
By Giri, D K et al.·Published in Journal of comparative pathology·2011·Department of Veterinary Pathobiology, United States·View original on PubMed →
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Original publication title: Giant cell glioblastoma in the cerebrum of a Pembroke Welsh corgi.
- Species:
- dog
Plain-English summary
A 6-year-old female Pembroke Welsh corgi was brought to the vet after showing signs of unsteady walking (ataxia) and heavy panting for about a month. As her condition worsened, she stopped eating and began circling to the left. Sadly, a mass was found in her brain during a post-mortem examination, leading to a diagnosis of giant cell glioblastoma, a type of brain tumor. This type of tumor is more common in humans but is rarely seen in dogs. Unfortunately, the dog did not recover due to the severity of the condition.
People also search for: dog brain tumor symptoms · Pembroke Welsh corgi ataxia · giant cell glioblastoma in dogs
Abstract
A 6-year-old, neutered female Pembroke Welsh corgi was presented with a 1-month history of ataxia and panting. The clinical signs progressed until the dog became anorexic, obtunded and exhibited circling to the left. At necropsy examination, a mass was detected in the left forebrain, impinging on the cribriform plate. Microscopically, the mass was composed of sheets of round to pleomorphic neoplastic cells with vacuolated cytoplasm. Nuclear atypia, anisocytosis and anisokaryosis were common. Numerous bizarre, multinucleated giant cells containing 60 or more nuclei and giant mononuclear cells were present. The matrix contained abundant reticulin. Immunohistochemistry revealed the neoplastic cells uniformly to express vimentin, and a small number of neoplastic cells expressed glial fibrillary acid protein. A diagnosis of giant cell glioblastoma was made. Although well recognized in man, this tumour has been documented rarely in the veterinary literature.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21146179/