Peer-reviewed veterinary case report
Giant cell tumor of soft parts. A report of an equine and a feline case.
- Journal:
- Veterinary pathology
- Year:
- 1975
- Authors:
- Ford, G H et al.
Plain-English summary
In this study, a 12-year-old Arabian mare and a 7.5-year-old female cat had tumors removed from their bodies that were similar to a type of cancer seen in humans called a malignant giant cell tumor of soft parts. The tumors showed specific features under the microscope, including large cells with multiple nuclei and other cell types that indicated they were aggressive. The researchers noted that these tumors behaved like the human version, and the structure of the giant cells suggested they came from connective tissue. Overall, the findings highlight that these tumors can occur in both horses and cats, but the abstract does not provide information on the treatment or outcome for these cases.
Abstract
Masses removed from the superficial fascia of the jugular groove of a 12-year-old Arabian mare and from the femoral canal of a 7 1/2-year-old female cat appeared to be counterparts of the human malignant giant cell tumor of soft parts, even recapitulating the clinical behavior of the respective subgroups. Histologically, both neoplasms contained the characteristic features of the malignant giant cell tumor of soft parts: large multinucleate giant cells, pleomorphic mononuclear giant cells, histiocytes, fibroblasts and fibrocytes that were sometimes sarcomatous, and foci of hemorrhage and necrosis. Ultrastructural characteristics of the giant cells suggest mesenchymal origin with osteoblastic or chondroblastic differentiation.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/1229057/