Peer-reviewed veterinary case report
Dog with glomerulocystic kidney and chronic renal failure signs
By Takahashi, M et al.·Published in Journal of comparative pathology·2005·Department of Veterinary Pathology, Japan·View original on PubMed →
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Original publication title: Glomerulocystic kidney in a domestic dog.
- Species:
- dog
Plain-English summary
A 5-year-old female Shiba Inu was diagnosed with glomerulocystic kidney disease, which led to chronic kidney failure. The dog showed symptoms like convulsions, vomiting, and diarrhea before passing away. Blood tests revealed anemia and high levels of waste products in the blood, indicating kidney dysfunction. Unfortunately, despite the findings, there was no successful treatment to reverse the kidney damage, and the dog ultimately did not survive.
People also search for: dog kidney disease symptoms · Shiba Inu vomiting and diarrhea · chronic renal failure in dogs
Abstract
Glomerulocystic kidney was diagnosed in a 5-year-old female Shiba dog, which died from chronic renal failure with convulsions, vomiting and diarrhoea. Haematological examination revealed non-regenerating anaemia, azotaemia and high serum creatinine. Grossly, both kidneys were mildly atrophic with multiple small cysts in the cortex. Histopathological examination revealed marked dilatation of Bowman's space, often with glomerular atrophy or loss, and mild interstitial fibrosis. Bowman's basement membranes (BMs) were tortuous and thickened, with patchy calcification. Glomerulo-tubular junctions in the urinary pole side of the kidneys had a stenotic appearance associated with thickening of Bowman's BMs and calcification. Focal interstitial fibrosis around the glomerulo-tubular junction was also found. Continuity with the proximal tubule was evident in cystic glomeruli. Ultrastructurally, marked thickening of Bowman's BMs with many granular deposits in the urinary pole side was observed. The findings indicate that glomerular cystic changes may have developed as a consequence of glomerulo-tubular junctional stenosis due to thickened Bowman's BMs and focal periglomerular fibrosis in the urinary pole side of the kidneys.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16024037/