Peer-reviewed veterinary case report
Skin sores and diabetes linked to pancreatic tumors in two dogs
By Gross, T L et al.·Published in Journal of the American Veterinary Medical Association·1990·California Dermatopathology Service, United States·View original on PubMed →
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Original publication title: Glucagon-producing pancreatic endocrine tumors in two dogs with superficial necrolytic dermatitis.
- Species:
- dog
Plain-English summary
Two dogs with pancreatic tumors developed a serious skin condition called superficial necrolytic dermatitis, which caused redness and crusting on their footpads, face, and other areas. This skin issue appeared months before they were diagnosed with diabetes. Blood tests showed signs of liver disease, which is often linked to this type of skin problem. The dogs were treated for their symptoms, but the underlying tumors and diabetes complicated their health. It's important for pet owners to be aware of how skin issues can sometimes indicate more serious health problems like tumors or diabetes.
People also search for: dog skin problems · diabetic skin issues in dogs · glucagonoma syndrome in dogs · dog liver disease symptoms · treatment for dog skin dermatitis
Abstract
A newly recognized disease in dogs, ulcerative dermatosis associated with diabetes mellitus (diabetic dermatopathy), was diagnosed in 2 dogs with pancreatic endocrine tumors that had immunohistologic evidence of glucagon production. Dogs developed diabetes mellitus in the later stages of the illness, months after the skin disease was first observed. Liver disease was identified and characterized by high serum alkaline phosphatase and alanine transaminase activities. Clinically, erythema and crusting involved the footpads, the face, perioral and genital skin, and ventrum. Histologically, skin lesions were intercellular and intracellular edema and necrosis of the upper half of the epidermis and diffuse parakeratosis. Clinically and histologically, skin lesions closely resembled necrolytic migratory erythema of people, a skin disease that usually is associated with a glucagon-secreting pancreatic endocrine tumor and diabetes mellitus (glucagonoma syndrome): The morphologically descriptive term, superficial necrolytic dermatitis, was preferred over the previously proposed names hepatocutaneous syndrome and diabetic dermatopathy, which each connote only a single feature of the disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/2276959/