Peer-reviewed veterinary case report
Filly with laminitis and liver issues after steroid treatment
By Ryu, Seung Ho et al.·Published in Journal of veterinary science·2004·Equine Hospital, South Korea·View original on PubMed →
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Original publication title: Glucocorticoid-induced laminitis with hepatopathy in a Thoroughbred filly.
- Species:
- horse
Plain-English summary
A 3-year-old Thoroughbred filly was taken to a veterinary hospital because she was having blood in her urine, eating less than usual, losing weight, and seemed very tired. About 25 days before her visit, she had been treated for lameness in her leg with a steroid called triamcinolone acetonide, which she received daily for 10 days. Tests showed signs of liver problems and laminitis (a painful condition affecting the hooves), likely caused by the steroid treatment. Although acupuncture helped improve her blood in the urine, the prognosis for her laminitis was still uncertain, highlighting the importance of early detection and management of this condition in horses treated with steroids. Overall, the treatment had mixed results, with some improvement in her urinary symptoms but ongoing concerns about her laminitis.
Abstract
A 3-year-old Thoroughbred filly was referred to the Equine Hospital, Korea Racing Association for evaluation of hematuria, inappetite, weight loss and depression. From 25 days prior to admission, the horse was treated for right carpal lameness with 20 mg intramuscular administration of triamcinolone acetonide per day for consecutive 10 days by a local veterinarian. Clinical and laboratory findings included vaginal hyperemia, flare in bladder wall, neutrophilia, lymphopenia, polyuria, polydipsia and laminitis in the end. High activities of aspartate transaminase and gamma glutamyltransferase and high concentration of total bilirubin indicated hepatopathy. Further hematology, serum biochemistry and urinalysis did not reveal any abnormalities. Medical history, physical and clinicopathologic findings suggest that the laminitis and hepatopathy in this horse were most likely induced by repeated administration of exogenous corticosteroid. However, guarded prognosis of treating laminitis undermined the benefit of improvement of hematuria following electroacupuncture stimulation. The combined stimulation of kidney related acupoints (Shen Peng, Shen Shu), lumber related acupoints (Yao Qian, Yao Zhong) and associate acupoints (Guan Yuan Shu, Bai Hui) at 5Hz, 1-2V, for 40 minutes was of value in the treatment of hematuria. This case shows that horses under steroids may exhibit laminitis and steroid hepatopathy. Early recognition and good management of laminitis are important in the limitation of complications.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15365245/