Peer-reviewed veterinary case report
Glycolysis blocker helps photodynamic therapy treat horse sarcoids
By Golding, J P et al.·Published in Veterinary and comparative oncology·2017·School of Life, United Kingdom·View original on PubMed →
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Original publication title: Glycolysis inhibition improves photodynamic therapy response rates for equine sarcoids.
- Species:
- horse
Plain-English summary
A horse with sarcoids, which are skin tumors, was treated using a new method that combined photodynamic therapy (PDT) with a glycolysis inhibitor called lonidamine. This approach helped the treatment penetrate deeper into the tumors and significantly improved the effectiveness of PDT. After one month, 93% of the treated sarcoids showed a positive response, compared to only 14% with the standard PDT method. This new combination treatment appears to be a promising option for managing equine sarcoids.
People also search for: horse sarcoid treatment · photodynamic therapy for equine tumors · lonidamine for horse skin tumors
Abstract
Photodynamic therapy (PDT) holds great promise in treating veterinary and human dermatological neoplasms, including equine sarcoids, but is currently hindered by the amount of photosensitiser and light that can be delivered to lesions thicker than around 2 mm, and by the intrinsic antioxidant defences of tumour cells. We have developed a new PDT technique that combines an efficient transdermal penetration enhancer solution, for topical delivery of 5-aminolevulinic acid (ALA) photosensitiser, with acute topical post-PDT application of the glycolysis inhibitor lonidamine. We show that the new PDT combination treatment selectively kills sarcoid cells in vitro, with repeated rounds of treatment increasing sarcoid sensitisation to PDT. In vivo, ALA PDT followed by 600 μM lonidamine substantially improves treatment outcomes for occult, verrucous, nodular and fibroblastic sarcoids after 1 month (93% treatment response in 27 sarcoids), compared with PDT using only ALA (14% treatment response in 7 sarcoids).
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28127949/