Peer-reviewed veterinary case report
Gold nanoparticles help radiation kill feline injection site sarcoma
By Benton, J Z et al.·Published in Research in veterinary science·2018·Department of Biosciences and Diagnostic Imaging, United States·View original on PubMed →
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Original publication title: Gold nanoparticles enhance radiation sensitization and suppress colony formation in a feline injection site sarcoma cell line, in vitro.
- Species:
- cat
Plain-English summary
A study looked at how gold nanoparticles could help treat injection site sarcomas (ISS), a type of aggressive cancer in cats often linked to vaccinations. Researchers found that these nanoparticles not only reduced the growth of cancer cells but also worked better when combined with radiation therapy. While the nanoparticles didn't significantly change the immediate health of the cancer cells, they did prevent the cells from forming new colonies, which is crucial for cancer spread. This suggests that gold nanoparticles could be a promising long-term treatment option for managing ISS in cats.
People also search for: cat injection site sarcoma treatment · gold nanoparticles for cat cancer · feline cancer radiation therapy
Abstract
Injection Site Sarcomas (ISS) are highly invasive feline malignant tumors that are frequently associated with routine vaccination. Current treatment modalities include chemotherapy, radiation, and radical surgery. ISS have been shown to be one of the most treatment resistant of feline cancers with high rates of recurrence. Previous studies have shown that gold and other high atomic number nanoparticles have the ability to increase the dose of radiation deposited into tissue by generating secondary electrons. The focus of the current study was to assess the effects of gold nanoparticles (AuNP) on ISS cytotoxicity and colony formation both as a standalone treatment and in combination with electron beam radiation. Cells from an established ISS cell line were co-cultured with 15nm AuNP at 0.0, 0.25, 0.5, 1.0, 2.0 and 4.0mM. AuNP cytotoxicity was evaluated by assessing changes in cellularity, cell proliferation, cell cycle and viability/apoptosis/necrosis. The radiosensitizing potential of AuNP on ISS replication was assessed by the clonogenic assay. AuNP were found to significantly decrease cellular proliferation. However, the acute viability and cell cycle of ISS was not significantly altered. Interestingly, AuNP alone were shown to significantly impair colony formation. In the presence of 9MeV electron radiation, AuNP numerically decreased colony formation in ISS cells compared to cells treated with radiation only. AuNP may have efficacy as a long term therapeutic agent for decreasing ISS growth.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29220723/