Peer-reviewed veterinary case report
Rare granulocytic tumor called myeloid sarcoma found in 3 dogs
By Ubiali, Alessandra et al.·Published in Veterinary pathology·2025·University of Milan, Italy·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Granulocytic neoplasm suggestive of primary myeloid sarcoma in 3 dogs.
- Species:
- dog
Plain-English summary
Three dogs, aged between 6 and 11 years, were diagnosed with a rare type of tumor called myeloid sarcoma, which affected their lymph nodes and other areas. These tumors were confirmed to be of granulocytic origin, meaning they came from a specific type of blood cell. Unfortunately, despite attempts at chemotherapy, the tumors were aggressive and led to poor outcomes for the dogs. This type of cancer is uncommon in pets, making diagnosis and treatment challenging.
People also search for: dog tumor in lymph nodes · myeloid sarcoma in dogs · dog cancer treatment options
Abstract
Myeloid sarcoma (MS) is a solid tumor of granulocytic origin with extramedullary localization. This tumor is rare in humans and animals. The diagnostic approach is heterogeneous, and the definitive diagnosis may be difficult to achieve. Primary MS has never been described as a spontaneous neoplasm in companion dogs. Two purebred and 1 mixed-breed dogs, 6- to 11-year-old, developed round cell tumors in the mediastinum, lymph nodes (LNs) and tonsils, and LNs, respectively. Granulocytic origin and exclusion of lymphoid lineage were confirmed by flow cytometry, supported by immunohistochemistry or immunocytochemistry. Pivotal to the diagnosis were positive labeling for myeloid (CD11b, CD14) and hematopoietic precursors (CD34) markers, along with negative labeling for lymphoid markers. Blood and bone marrow infiltration were not detected at initial diagnosis, excluding acute myeloid leukemia. The behavior of these tumors was aggressive, resulting in poor clinical outcomes, even when chemotherapy was attempted.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38842063/