Peer-reviewed veterinary case report
Canine haemangiopericytoma tumor types and prognosis explained
By Mazzei, Maurizio et al.·Published in Veterinary dermatology·2002·Department of Animal Pathology, Italy·View original on PubMed →
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Original publication title: Haemangiopericytoma: histological spectrum, immunohistochemical characterization and prognosis.
- Species:
- dog
Plain-English summary
A group of dogs diagnosed with a type of tumor called haemangiopericytoma (a vascular tumor) were studied to understand its characteristics and outcomes. Out of 31 dogs, 23 were monitored for two years, and 6 of them experienced tumor recurrence or spread to other areas. The study found that certain tumor patterns and locations were linked to a worse prognosis. This information can help veterinarians better predict outcomes and tailor treatments for dogs with this type of tumor.
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Abstract
Canine haemangiopericytoma (CHP) is a vascular neoplasm thought to be derived from pericytes. The histological pattern and immunohistochemical profile were studied in 31 CHPs. Twenty-three subjects were followed for 2 years to evaluate the correlation among tumour location, histotype, immunostaining and outcome of the disease. Of the 31 CHPs examined, 20 exhibited a perivascular whorled pattern, 8 were storiform and 3 were epithelioid. All tumours were positive for vimentin and negative for cytokeratin, factor VIII-related antigen, glial fibrillary acidic protein and S-100 protein. Seventeen CHPs were positive for actin and nine co-expressed desmin. Six CHPs were also positive for CD34 antigen. The panel of immunohistochemical markers used confirmed the vascular lineage of CHP and aided in the exclusion of other mesenchymal tumours. Of the 23 dogs submitted to follow-up, 6 had recurrence or metastases of the primary tumour. The epithelioid pattern or a noncutaneous location were associated with a poorer prognosis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/11896966/