Peer-reviewed veterinary case report
Tumor on thigh of 10-year-old Persian cat explained
By A. Blutke et al.·Published in Veterinární Medicína·2012·Institute of Veterinary Pathology at the Centre for Clinical Veterinary Medicine, Ludwig-Maximilians-Universitaet München, Munich, Germany, CZ·View original on DOAJ →
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Original publication title: Hemangiopericytoma in a cat: a case report
- Species:
- cat
Plain-English summary
A 10-year-old Persian cat was found to have a large, unusual tumor on its thigh that measured about 7 centimeters. The tumor was dense and multilobulated, and after examination, it was diagnosed as a hemangiopericytoma, which is a rare type of tumor in cats. The tumor showed signs of necrosis and was growing into the surrounding muscle. This case is notable as it is only the second reported instance of this type of tumor in cats. Treatment details were not provided, but early diagnosis is crucial for managing such rare tumors.
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Abstract
In dogs and men, hemangiopericytoma is a well-recognised neoplasm, thought to originate from vascular pericytes. In cats, however, hemangiopericytoma is an extremely rare finding. The present report describes the pathological features of a 7-cm-diameter, dense, white, multilobulated tumour-like growth on the thigh of a ten-year-old Persian cat. Histologically, the mass consisted of polygonal neoplastic cells, concentrically arranged around thin-walled endothelium-lined blood vessels occasionally forming typical staghorn-configurations. In reticulin-stained sections, a dense meshwork of argyrophilic collagen fibres was evident, surrounding the central vessels and separating individual tumour cells. Within the tumour tissue, there were areas of extensive necrosis and degeneration. In the periphery, the tumour displayed a moderate infiltrative growth into the adjacent musculature. Immunohistochemical analysis revealed strong diffuse cytoplasmatic immunoreactivity for vimentin, a focal immunoreactivity for S-100, and a weak interstitial staining for laminin, whereas neoplastic cells stained negative for cytokeratin, desmin, actin, calponin, von Willebrand factor, glial fibrillary acidic protein, neuron specific enolase, CD79a, MAC387, lysozyme and MHCII. Ultrastructurally, the neoplastic cells contained few intracytoplasmatic filaments, and were surrounded by interlacing bundles of intercellular long-spacing collagen fibres. Occasionally, desmosome-like intermediate junctions were observed between neighbouring tumour cells. On the basis of histomorphology, ultrastructure and immunohistochemical reactivity, the neoplasm was diagnosed as a hemangiopericytoma, representing the second reported case of this rare tumour entity in a cat.
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Search related cases →Original publication on DOAJ: https://doi.org/10.17221/5958-VETMED