Peer-reviewed veterinary case report
Blood changes after total body irradiation and stem cell transplant
By Escobar, C et al.·Published in Veterinary pathology·2012·Department of Population Health and Pathobiology, United States·View original on PubMed →
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Original publication title: Hematologic changes after total body irradiation and autologous transplantation of hematopoietic peripheral blood progenitor cells in dogs with lymphoma.
- Species:
- dog
Plain-English summary
A group of dogs with lymphoma underwent a special treatment involving total body irradiation followed by a transplant of their own blood cells to help fight the disease. After the procedure, the dogs experienced significant drops in their white blood cells and platelets, but by day 12, all had recovered enough white blood cells to be considered stable. While some issues with low platelets continued for several weeks, all dogs were doing well and appeared healthy when they were sent home. This treatment showed promise in helping dogs with lymphoma recover their blood cell counts.
People also search for: dog lymphoma treatment · total body irradiation side effects · dog blood cell transplant recovery
Abstract
Dogs with and without lymphoma have undergone hematopoietic cell transplantation in a research setting for decades. North Carolina State University is currently treating dogs with B- and T-cell lymphoma in a clinical setting with autologous peripheral blood progenitor cell transplants, using peripheral blood CD34+ progenitor cells harvested using an apheresis machine. Complete blood counts were performed daily for 15 to 19 days posttransplantation to monitor peripheral blood cell nadirs and subsequent CD34+ cell engraftment. This study documents the hematologic toxicities of total body irradiation in 10 dogs and the subsequent recovery of the affected cell lines after peripheral blood progenitor cell transplant, indicating successful CD34+ engraftment. All peripheral blood cell lines, excluding red blood cells, experienced grade 4 toxicities. All dogs had ≥ 500 neutrophils/μl by day 12, while thrombocytopenia persisted for many weeks. All dogs were clinically normal at discharge.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21670196/