Peer-reviewed veterinary case report
Lomustine treatment effects and blood risks in cats with tumors
By Fan, Timothy M et al.·Published in Journal of the American Animal Hospital Association·2002·Department of Veterinary Medicine, United States·View original on PubMed →
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Original publication title: Hematological toxicity and therapeutic efficacy of lomustine in 20 tumor-bearing cats: critical assessment of a practical dosing regimen.
- Species:
- cat
Plain-English summary
Five cats with tumors were treated with an oral medication called lomustine, given every three weeks. While some cats experienced mild side effects like low white blood cell and platelet counts, severe reactions were rare. Notably, two cats with lymphoma, two with fibrosarcoma, and one with multiple myeloma showed improvement in their condition after treatment. The results suggested that higher doses of lomustine might lead to better outcomes for these cats.
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Abstract
Twenty cats with spontaneously arising tumors received oral lomustine at a dose range of 32 to 59 mg/m2 every 21 days. Due to biohazard concerns associated with lomustine capsule reformulation, a standardized 10-mg capsule dosage was used for all cats regardless of body weight. Severe hematological toxicity was infrequent, with the incidence of either grade III or IV neutropenia and thrombocytopenia being 4.1% and 1.0%, respectively. Cats receiving higher cumulative doses of lomustine trended toward a greater likelihood for progressive neutropenia (P=0.07). Two cats with lymphoma, two cats with fibrosarcoma, and one cat with multiple myeloma achieved a measurable partial response to lomustine therapy. Cats treated with higher dosages of lomustine trended toward statistically significant higher response rates (P=0.07).
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/12118689/