Peer-reviewed veterinary case report
Hemolytic uremic syndrome causing kidney failure in dogs
By Holloway, S et al.·Published in Journal of veterinary internal medicine·1993·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Hemolytic uremic syndrome in dogs.
- Species:
- dog
Plain-English summary
Three dogs developed serious kidney problems after experiencing severe vomiting and diarrhea, a condition known as hemorrhagic gastroenteritis. They showed signs of acute kidney failure, with high levels of waste products in their blood. One dog responded to treatment with a combination of medications that helped restart urine production, but unfortunately, the other two did not survive. This case highlights a serious condition in dogs that resembles a similar syndrome seen in humans.
People also search for: dog kidney failure symptoms · hemorrhagic gastroenteritis in dogs · treatment for dog acute renal failure
Abstract
A disease syndrome similar to the hemolytic uremic syndrome of people is described in three dogs with acute renal failure. In each dog, hemorrhagic gastroenteritis preceded the onset of anuric acute renal failure. Evidence of microangiopathic hemolytic anemia (schizocytes, thrombocytopenia, and increased concentrations of fibrin split products) was present in the three dogs. Serum chemistry results showed increased concentrations of blood urea nitrogen, creatinine, and phosphorus. Ultrasound examination performed in one dog revealed increased echogenicity of the renal cortices. Treatment for anuric acute renal failure using a continuous dopamine and furosemide infusion established urine production in one of three dogs. Microscopic examination of tissue from the two dogs that underwent necropsy showed occlusion of the renal vasculature by fibrin thrombi consistent with microangiopathic arteriolar thrombosis. The pathophysiology and current knowledge of human hemolytic uremic syndrome is compared with hemolytic uremic syndrome in these dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/8246211/