Peer-reviewed veterinary case report
Male crossbreed cat with severe bleeding from hemophilia B and factor
By Lutze, Gerd et al.·Published in Berliner und Munchener tierarztliche Wochenschrift·2005·Institut fü·View original on PubMed →
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Original publication title: [Hemophilia B (factor IX deficiency) with concomitant factor XII degradation in a male crossbreed cat].
- Species:
- cat
Plain-English summary
A male crossbreed cat had serious bleeding issues, showing symptoms like deep bruises, prolonged bleeding after injuries, and lameness. He developed severe anemia, with his blood levels dropping dangerously low. The vet diagnosed him with Hemophilia B, a condition where the blood doesn't clot properly due to a deficiency in factor IX. Unfortunately, despite treatment focused on managing the symptoms, the cat's condition was too severe, and he did not survive due to the anemia.
People also search for: cat bleeding disorder · cat hemophilia treatment · why is my cat limping and bleeding · cat anemia symptoms · factor IX deficiency in cats
Abstract
A male cat suffered from a severe haemorrhagic disorder manifesting as deep, partly infected cutaneous haematomas, enhanced and prolonged bleeding after injuries and subsequent lameness at several occasions. Bleeding resulted in severe anaemia with haematocrit falling to as low as 0.10 L/L. Haemophilia B was diagnosed based on factor IX deficiency with a functional residual activity of 5% and factor IX antigen of 8%, respectively. Additionally, factor XII activity was reduced to 32% of normal. The mutation 31217G==>A in exon 8 of the factor IX gene, predicting the amino acid exchange G366R was identified as the cause of moderate factor IX deficiency. This is the first mutation identified in cats with haemophilia B. Treatment was limited to local therapy and palliation, insufficient to prevent lethal outcome due to severe anaemia.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15918491/