Peer-reviewed veterinary case report
Blood clotting problems in dogs with immune-mediated hemolytic anemia
By Scott-Moncrieff, J C et al.·Published in Journal of the American Animal Hospital Association·2001·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Hemostatic abnormalities in dogs with primary immune-mediated hemolytic anemia.
- Species:
- dog
Plain-English summary
A group of 20 dogs with a serious condition called primary immune-mediated hemolytic anemia (where the immune system attacks red blood cells) had their blood clotting factors tested. Many showed signs of abnormal blood clotting, with some having increased levels of certain proteins that indicate clotting issues. Unfortunately, some dogs experienced complications like blood clots, which were common in those that did not survive. The study found that while many dogs had serious blood abnormalities, these did not directly predict which dogs would die.
People also search for: dog immune-mediated hemolytic anemia symptoms · dog blood clotting issues · treatment for dog anemia
Abstract
Hemostatic parameters were prospectively measured in 20 dogs with primary immune-mediated hemolytic anemia. Eight of 20 dogs had received prior treatment with prednisone. Activated partial thromboplastin time was increased in nine dogs; one-stage prothrombin time was increased in two dogs; fibrinogen concentration was increased in 17 dogs; and antithrombin activity was decreased in 10 dogs. Fibrin(ogen) degradation products concentration was increased in 12 dogs, and D-dimer concentration was increased in 16 dogs. Four or more laboratory criteria of disseminated intravascular coagulation (DIC) were present in nine dogs, and three criteria of DIC were found in four additional dogs. Thromboembolism was the most common finding in the dogs that died. In this study population, mortality was not significantly associated with any clinical finding or laboratory variable.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/11361112/