Peer-reviewed veterinary case report
Liver tumor called hepatoblastoma found in an 8-year-old Abyssinian
By Ano, N et al.·Published in Veterinary pathology·2011·Marupi Lifetech Co, Japan·View original on PubMed →
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Original publication title: Hepatoblastoma in a cat.
- Species:
- cat
Plain-English summary
An 8-year-old Abyssinian cat was diagnosed with a liver tumor called hepatoblastoma after showing no signs of improvement following a biopsy. The tumor was made up of abnormal liver cells and was identified through various tests that looked for specific markers. Unfortunately, despite the diagnosis and attempts to treat the condition, the cat passed away shortly after the biopsy without any clinical improvement.
People also search for: cat liver tumor symptoms · Abyssinian cat cancer · hepatoblastoma treatment in cats
Abstract
Hepatoblastomas are neoplasms that originate from putative pluripotential stem cells of the liver. A hepatic mass from an 8-year-old Abyssinian cat was composed of cords and sheets of neoplastic cells, with scattered rosettes and small ductal structures. Most neoplastic cells had a pale eosinophilic cytoplasm and a round to ovoid nucleus. The tumor also had short spindle cells with an oval nucleus. Immunohistochemically, neoplastic cells were weakly positive for embryonic hepatocellular markers, such as alpha-fetoprotein and cytokeratin (CK) 8/18, but negative for the hepatocellular marker Hepatocyte Paraffin 1. The cells were also positive for CD56/neural cell adhesion molecule and for the biliary epithelial markers CK 7, CK 8/18, CK CAM5.2, and vimentin, but negative for CK 20. Some neoplastic cells expressed neuroectodermal or neuroendocrine markers, such as protein gene product 9.5 and synaptophysin, but were negative for chromogranin A and not argyrophilic by the Grimelius technique. The cat died soon after the biopsy without clinical improvement.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21118798/