Peer-reviewed veterinary case report
Dog diagnosed with aggressive hepatosplenic lymphoma affecting liver
By Fry, M M et al.·Published in Veterinary pathology·2003·Department of Pathology, United States·View original on PubMed →
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Original publication title: Hepatosplenic lymphoma in a dog.
- Species:
- dog
Plain-English summary
A 9-year-old mixed-breed dog was diagnosed with hepatosplenic lymphoma, a type of cancer that affects the liver and spleen. The dog showed signs of illness, including lethargy and weight loss, and tests revealed abnormalities in blood work. Unfortunately, despite efforts to diagnose and treat the condition, the aggressive nature of the lymphoma led to a poor outcome, and the dog passed away shortly after diagnosis. This case is notable as it is the first reported instance of this specific type of lymphoma in dogs.
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Abstract
We describe a case of a dog with hepatosplenic lymphoma, a disease characterized by infiltration of the liver, spleen, and bone marrow with gammadelta T cells, absence of peripheral lymphadenopathy, and an aggressive clinical course. Physical examination findings, hematologic and biochemical abnormalities, and clinical course of the disease in this patient were similar to those in humans. Immunophenotyping of liver and spleen aspirates supported an antemortem diagnosis of T-cell lymphoma consistent with hepatosplenic lymphoma. The diagnosis was confirmed postmortem by a combination of routine histopathology, showing a consistent pattern of organ involvement, and immunohistochemistry showing the infiltrating neoplastic lymphocytes to be T cells expressing the gammadelta T-cell receptor. To our knowledge, this is the first reported case of hepatosplenic lymphoma in a dog.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/12949413/