Peer-reviewed veterinary case report
High tissue factor levels in dogs with immune-mediated anemia
By Piek, C J et al.·Published in Veterinary immunology and immunopathology·2011·Department of Clinical Sciences of Companion Animals, Netherlands·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: High intravascular tissue factor expression in dogs with idiopathic immune-mediated haemolytic anaemia.
- Species:
- dog
Plain-English summary
A dog with idiopathic immune-mediated hemolytic anemia (IMHA) can face serious health risks, especially in the first two weeks after diagnosis. This condition leads to the dog's immune system attacking its own red blood cells, causing symptoms like weakness and pale gums. The study found that dogs with IMHA showed significant inflammation and changes in blood clotting factors, which can worsen their condition. Unfortunately, many dogs with IMHA have a high risk of mortality due to these complications. Treatment often involves managing the immune response and supporting blood health, but the prognosis can be serious.
People also search for: dog IMHA symptoms · dog anemia treatment · why is my dog weak and pale
Abstract
A high mortality occurs in dogs with idiopathic immune-mediated haemolytic anaemia (IMHA) during the first 2 weeks after the diagnosis. The aim of this study was to investigate the inflammatory response and coagulation abnormalities in dogs with IMHA in relation to the prognosis and to establish the contribution of whole blood tissue factor (TF) and IL-8 gene expressions. Gene expressions in dogs with IMHA were compared to healthy dogs, dogs with DIC, dogs with sepsis, and in two groups of dogs that underwent intensive care treatment but had no evidence for either DIC or sepsis. The whole blood TF and IL-8 expressions were up regulated in all non-IMHA groups. Similarly, the TF expression in IMHA dogs was high, but the intravascular IL-8 expression was not increased. The dogs with IMHA had a pronounced inflammatory response that included a high WBC, left shift and monocytosis in comparison to the other disease groups. Coagulation factor activities in IMHA dogs were decreased fitting consumptive coagulopathy and the acute phase proteins FVIII and fibrinogen were increased. The platelet parameters suggested platelet activation and high platelet turnover in IMHA dogs. The model that best explained mortality contained monocytosis, increased activated partial thromboplastin time and elevated creatinine. Whole blood TF gene expression is up regulated and may contribute to consumptive coagulopathy in dogs with IMHA. Increased TF expression by activated platelets is an alternative explanation and should be investigated.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21899896/