Peer-reviewed veterinary case report
High lysozyme levels in dog with acute myeloid leukemia
By Tasca, Silvia et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2010·Clinica San Marco, Italy·View original on PubMed →
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Original publication title: High serum and urine lysozyme levels in a dog with acute myeloid leukemia.
- Species:
- dog
Plain-English summary
A 2-year-old female German Shepherd was brought to the vet with facial nerve paralysis and was diagnosed with acute myelomonocytic leukemia, a type of blood cancer. During testing, the vet found high levels of a protein called lysozyme in both her blood and urine, which indicated kidney issues despite no signs of kidney failure. The dog was experiencing proteinuria, meaning there was excess protein in her urine. The vet used this information to help manage her condition, but the specific treatment details and outcome were not provided.
People also search for: German Shepherd facial paralysis · dog leukemia symptoms · high protein in urine in dogs
Abstract
A 2-year-old, female German Shepherd Dog with facial nerve paralysis was diagnosed with acute myelomonocytic leukemia based on clinical, cytologic, and immunologic findings. Proteinuria (urine proteincreatinine ratio = 1.5) occurred in the absence of renal failure. Qualitative assessment of proteinuria by sodium dodecyl sulfate-agarose gel electrophoresis revealed a broad band with a molecular weight of approximately 15 kDa that was compatible with lysozyme (LZM). A diagnosis of tubular proteinuria was made, and a chemical evaluation of LZM in serum and urine samples was performed using a turbidimetric assay. The LZM concentrations were 24.5 mg/l (reference interval: 2.5-8.0 mg/l) and 274.5 mg/l (reference interval: <2 mg/l) in serum and urine, respectively.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20093697/