Peer-reviewed veterinary case report
Malignant uterine tumor found in an 11-year-old cat
By Hirota, Teruaki et al.·Published in Journal of comparative pathology·2024·Joint Department of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: Highly malignant endometrial stromal sarcoma in a cat.
- Species:
- cat
Plain-English summary
A worried owner brought in their 11-year-old female Persian cat for surgery due to an enlarged uterus with thickened walls. During the operation, the vet found swollen areas and multiple nodules in the uterus, which were later diagnosed as a highly malignant tumor called endometrial stromal sarcoma (ESS). This type of cancer can invade surrounding tissues and has been linked to hormone receptors. Unfortunately, the prognosis for this condition is serious, and further treatment options would need to be discussed with a veterinarian.
People also search for: cat uterine tumor · Persian cat cancer symptoms · endometrial stromal sarcoma treatment in cats
Abstract
An 11-year-old female Persian cat underwent ovariohysterectomy due to dilation of the uterine cavity with irregular thickening of the wall. Macroscopically, the middle and distal regions of the left uterine horn were swollen and the uterine wall was irregularly thickened due to the development of multiple coalescent, variably sized nodules. Microscopically, the nodules had originated in the endometrium and were composed of round to polygonal neoplastic cells arranged in dense sheets or ill-defined fascicles. The neoplastic cells had locally invaded the myometrium and reached the subserosa, with lymphovascular invasion. Immunohistochemically, the neoplastic cell population was partially positive for CD10, an established marker of endometrial stromal sarcoma (ESS) in humans, with focal and diffuse nuclear immunopositivity for oestrogen and progesterone receptors and immunonegativity for desmin and α-smooth muscle actin. Based on these findings, the uterine tumour was diagnosed as ESS and was considered to correspond morphologically to high-grade ESS in humans.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38011771/