Peer-reviewed veterinary case report
Cat with histiocytic sarcoma causing anemia and spleen enlargement
By Friedrichs, Kristen R. & Young, Karen M.·Published in Veterinary Clinical Pathology·2008·View original on Crossref →
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Original publication title: Histiocytic sarcoma of macrophage origin in a cat: case report with a literature review of feline histiocytic malignancies and comparison with canine hemophagocytic histiocytic sarcoma
- Species:
- cat
Plain-English summary
A 9-year-old neutered male domestic shorthair cat was found to have mild anemia during a routine check-up. Over the next several months, his condition worsened, leading to enlarged spleen and liver, and low platelet counts. Tests revealed a type of cancer called histiocytic sarcoma, which was affecting his spleen and liver. Unfortunately, this type of cancer is serious and can be challenging to treat. The cat's specific treatment details were not mentioned, but this case highlights a rare form of cancer in cats that resembles a similar condition seen in dogs.
People also search for: cat anemia symptoms · cat spleen cancer treatment · domestic shorthair histiocytic sarcoma
Abstract
Abstract:Mild nonregenerative anemia was detected in a 9‐year‐old neutered male domestic shorthair cat during a routine examination. Bone marrow core biopsy revealed erythroid hyperplasia; however, a specific cause was not identified. Over the next 8 months the anemia progressed, eventually becoming mildly regenerative, and moderate thrombocytopenia developed. On ultrasonographic examination, marked splenomegaly, mild hepatomegaly, and abdominal lymphadenopathy were found. Cytologic evaluation of splenic aspirates revealed increased numbers of mildly to moderately pleomorphic histiocytes that frequently had phagocytosed RBCs, leukocytes, and occasionally platelets. Histopathologic examination of the spleen and liver revealed effacement of splenic architecture by a histiocytic sarcoma (HS), and neoplastic histiocytes in hepatic sinusoids. A second bone marrow aspirate revealed neoplastic infiltration by similar cells. The histiocytes in all tissues were mildly to moderately pleomorphic and markedly erythrophagocytic. The immunophenotype of histiocytes in the spleen was CD1c−/CD11b+/CD18+/MHC‐II+, supporting a macrophage cell lineage. The clinical, pathologic, and immunophenotypic findings in this cat were similar to those in hemophagocytic HSs in dogs. To our knowledge, this is the first report of a HS of purported macrophage phenotype in a cat.
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Search related cases →Original publication on Crossref: https://doi.org/10.1111/j.1939-165x.2008.00005.x