Peer-reviewed veterinary case report
Seizures in dogs caused by brain histiocytic sarcoma tumors
By Thongtharb, Atigan et al.·Published in The Journal of veterinary medical science·2016·Department of Veterinary Pathology, Japan·View original on PubMed →
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Original publication title: Histological and immunohistochemical studies on primary intracranial canine histiocytic sarcomas.
- Species:
- dog
Plain-English summary
A group of 23 middle- to older-aged dogs with brain tumors were brought in for seizures, which were a common symptom. Imaging tests showed that the tumors were primarily located in the frontal lobe of the brain. The tumors were identified as histiocytic sarcomas, a type of aggressive cancer. Unfortunately, this condition is progressive and often fatal, but understanding its characteristics can help veterinarians provide better care. Treatment options may vary, and discussing the best approach with your vet is crucial for managing this serious diagnosis.
People also search for: dog seizure causes · brain tumor in dogs · histiocytic sarcoma treatment for dogs
Abstract
Histiocytic sarcoma is a progressive and fatal malignant neoplasm that mainly occurs in middle- to old-aged dogs. This study describes clinicopathological, histological and immunohistochemical characteristics of intracranial histiocytic sarcomas in 23 dogs. Magnetic resonance imaging and/or computed tomography of the brains revealed that the tumors mainly located in the cerebrum, particularly the frontal lobe. Seizure was a predominant clinical sign in most of the cases. Histologically, the tumor cells were morphologically classified into round/polygonal- and spindle-shaped cell types. There was a significant association between tumor cell types and hemophagocytic activity (P<0.05). However, there was no significant difference in other clinicopathological parameters and mitotic index between the 2 types. Immunohistochemically, tumor cells were strongly positive for HLA-DR, Iba-1 and CD204 in all the 23 cases, for iNOS in 20, for CD163 in 17, for CD208 (DC-LAMP) in 9, for lysozyme in 8 and for S100 in 5 cases. In addition, the Ki67-proliferative index showed range of 0.50-64.33% (Average 26.60 ± 3.81%). These observations suggest that canine primary intracranial histiocytic sarcomas tend to exhibit both dendritic cell and macrophage phenotypes of histiocytic differentiation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26668164/