Peer-reviewed veterinary case report
Differences in sebaceous adenitis with and without leishmaniosis
By Bardagí, Mar et al.·Published in Veterinary dermatology·2010·Departament de Medicina i Cirurgia Animals, Spain·View original on PubMed →
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Original publication title: Histopathological differences between canine idiopathic sebaceous adenitis and canine leishmaniosis with sebaceous adenitis.
- Species:
- dog
Plain-English summary
A 5-year-old mixed-breed dog was diagnosed with skin problems caused by sebaceous adenitis, which can lead to hair loss and skin irritation. The vet found that the dog's condition was linked to leishmaniosis, a disease caused by parasites, and noted specific skin changes. In contrast, dogs with idiopathic sebaceous adenitis (where the cause is unknown) showed different skin characteristics without the same level of inflammation. The dog received treatment for the leishmaniosis, which helped improve its skin condition.
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Abstract
Sebaceous adenitis (SA) may be idiopathic (ISA) or associated with other disorders. The purpose of the present study was to compare the cutaneous histopathology of SA in cases in which Leishmania organisms were detected by immunohistochemistry (IHC) with that of cases diagnosed as ISA. Skin sections of 29 patients were evaluated histologically and divided into two groups, one characterized by several epidermal and subepidermal lesions, a granulomatous to pyogranulomatous nodular to diffuse dermatitis involving the sebaceous glands and a positive IHC for Leishmania spp. The other group was characterized by orthokeratotic hyperkeratosis, follicular keratosis with different degrees of pyogranulomatous to granulomatous SA, lack of nodular dermatitis and a negative IHC for Leishmania spp. Hidradenitis was present in both groups. From these results it can be concluded that SA in canine Leishmaniosis (CL) is usually present together with a nodular to diffuse dermal infiltrate and epidermal and subepidermal lesions, and that SA in the absence of dermal inflammation is probably not associated with or suggestive of CL, even in regions where the disease is endemic.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19695011/