Peer-reviewed veterinary case report
Hormone receptor levels and tumor features in cat injection site
By Zanuncio, Virgínia V et al.·Published in Veterinary and comparative oncology·2021·Department of Medicine and Nursing, Brazil·View original on PubMed →
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Original publication title: Hormone receptor expression, clinical and histopathological analysis in feline injection site sarcomas.
- Species:
- cat
Plain-English summary
A group of cats with injection site sarcomas (FISS), a type of aggressive tumor that can develop at vaccination sites, were studied to understand the role of certain hormones in their growth. Most of the cats were around 10 years old, with tumors primarily located on their trunks. The researchers found that about 64% of the tumors expressed estrogen receptors, which seemed to be linked to how quickly the tumors were growing. Unfortunately, the study suggests that more research is needed to fully understand how these hormone levels affect the prognosis for cats with FISS.
People also search for: cat injection site sarcoma treatment · feline tumor growth hormones · signs of cancer in cats
Abstract
Feline injection site sarcomas (FISS) are aggressive, with high recurrence and rarely metastasising. The objective of this study was to evaluate, by immunohistochemistry, the expression of oestrogen (ER) and progesterone (PR) receptors in FISS and correlate them with clinical and histopathological aspects. This was a retrospective study with 51 cases of FISS. Immunohistochemistry was performed to detect vimentin, ER, PR and Ki67 expression. Clinical, histopathological and immunohistochemical characteristics were predictor variables and the expression of ER and PR were the dependent ones. Twenty-eight (55%) of the 51 FISS cases were female and 23 (45%) male with 10.7 ± 4.2 years and median tumour size of 3 cm (2.0-5.4). The trunk was the most affected site, with 38 cases (84%). Histological grade III was observed in 57% of the cases, considering differentiation score, necrosis and mitotic index. ER expression, positive in 64% of cases, was associated with the mitotic index (P = .05) and degree of pleomorphism (P = .04). PR was not associated with the variables and 63% of cases were negative for this receptor. Thus, ER expression can affect tumour growth. The knowledge on the FISS hormonal expression is important to clarify the pathophysiological mechanisms. Further studies are needed to predict the value of ER expression in the prognosis of FISS.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33211351/