Peer-reviewed veterinary case report
Hypercalcemia and chronic lymphocytic leukemia in a Giant Schnauzer
By Kleiter, M et al.·Published in Australian veterinary journal·2001·I. Medical Clinic for Small Animals and Horses·View original on PubMed →
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Original publication title: Hypercalcaemia associated with chronic lymphocytic leukaemia in a Giant Schnauzer.
- Species:
- dog
Plain-English summary
A 7-year-old male Giant Schnauzer was brought to the vet because he was severely vomiting, lethargic, losing weight, and drinking and urinating more than usual. Tests showed he had a high number of white blood cells, low red blood cells, and high calcium levels, which led to a diagnosis of chronic lymphocytic leukemia (a type of blood cancer) along with hypercalcemia (high calcium). The dog was treated with medications prednisolone and chlorambucil, and he responded well, remaining stable for about 8 months.
People also search for: Giant Schnauzer vomiting · dog weight loss and lethargy · chronic lymphocytic leukemia treatment · high calcium in dogs · dog cancer symptoms
Abstract
A 7-year-old male Giant Schnauzer was referred with a history of severe vomiting, lethargy, weight loss, polydipsia and polyuria. Detailed investigations revealed leucocytosis with a marked lymphocytosis, mild non-regenerative anaemia, thrombocytopenia, hypercalcaemia and azotaemia. Circulating lymphocytes were small and well-differentiated, and the same lymphoid population was present in bone marrow. Chronic lymphocyctic leukaemia with associated paraneoplastic hypercalcaemia was diagnosed. Immunohistochemical staining of a bone marrow biopsy revealed a neoplastic B-cell line expressing CD79. The dog responded to therapy with prednisolone and chlorambucil for a period of 8 months.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/11431998/