Peer-reviewed veterinary case report
Dog with high calcium and hormone from mammary cancer
By Bae, Bo-kyoung et al.·Published in Veterinary clinical pathology·2007·Department of Clinical Pathology, South Korea·View original on PubMed →
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Original publication title: Hypercalcemia and high parathyroid hormone-related peptide concentration in a dog with a complex mammary carcinoma.
- Species:
- dog
Plain-English summary
A 10-year-old female Dachshund was brought in because she had mammary lumps, was a bit lethargic, and was drinking and urinating more than usual. The vet found enlarged lymph nodes and high calcium levels in her blood. After removing the mammary masses, tests confirmed she had a complex mammary carcinoma (a type of breast cancer). Three weeks after surgery, her calcium levels returned to normal, and her symptoms improved, indicating that the high calcium was related to her cancer.
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Abstract
A 10-year-old female Dachshund was presented with a history of mammary masses, slight lethargy, polyuria, and polydipsia. Physical examination findings included masses involving the first, second, and fourth mammary glands of the left side. The mandibular, axillary, and right popliteal lymph nodes were mildly enlarged. Serum chemistry results included hypercalcemia (13.9 mg/dL, reference interval 8.0-11.5 mg/dL). Although intact parathyroid hormone (PTH) concentration (1.05 pmol/L) was below the reference interval (2-13 pmol/L), PTH-related protein (PTHrP) concentration was markedly increased (9.40 pmol/L, reference value < 2 pmol/L). The masses were surgically removed, and the histopathologic diagnosis was complex mammary carcinoma. Three weeks after surgery, serum total calcium concentration had decreased to 10.5 mg/dL. Resolution of the hypercalcemia and clinical signs supported a diagnosis of humoral hypercalcemia of malignancy associated with mammary gland carcinoma.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18041707/