Peer-reviewed veterinary case report
Cat with intestinal T cell lymphoma and high eosinophils causing
By Barrs, V R et al.·Published in The Journal of small animal practice·2002·Feline Referral Centre, United Kingdom·View original on PubMed →
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Original publication title: Hypereosinophilic paraneoplastic syndrome in a cat with intestinal T cell lymphosarcoma.
- Species:
- cat
Plain-English summary
A 10-year-old female domestic shorthair cat was brought to the vet because she was losing weight, drinking a lot, and had diarrhea and vomiting. The vet found that her intestines were thickened and her lymph nodes were swollen. Blood tests showed a high number of eosinophils, a type of white blood cell, which can indicate an underlying issue. Although the cat initially responded to steroid treatment, her condition worsened, and she was ultimately euthanized. The diagnosis revealed she had intestinal T cell lymphosarcoma, a type of cancer affecting the intestines.
People also search for: cat weight loss vomiting · cat diarrhea treatment · cat cancer symptoms · eosinophilia in cats · T cell lymphoma in cats
Abstract
A 10-year-old, neutered female, domestic shorthair cat was presented with a recent history of weight loss, polydipsia, diarrhoea and vomiting. On physical examination, intestinal thickening and mesenteric lymph node enlargement were apparent. Clinical investigations revealed peripheral blood eosinophilia, eosinophilic abdominal effusion and eosinophilic mesenteric lymphadenitis. There was a temporary response to treatment with glucocorticoids but signs progressed and the cat was euthanased. On histology, there was eosinophilic infiltration and fibroplasia of intestine and mesenteric lymph nodes. Large aggregates of neoplastic round cells in the intestine and lymph nodes were identified as T lymphocytes using immunohistochemistry. A diagnosis of intestinal T cell lymphosarcoma was made. This case demonstrates that hypereosinophilic paraneoplastic syndrome may occur in cats with lymphosarcoma. Eosinophil chemotaxis may be a response to the production of interleukin-5 by neoplastic lymphocytes.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/12238505/