Peer-reviewed veterinary case report
High blood lipase in dogs with acute kidney injury and dialysis
By Bendeler, Kim S et al.·Published in Journal of veterinary internal medicine·2023·Small Animal Clinic·View original on PubMed →
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Original publication title: Hyperlipasemia in dogs with acute kidney injury treated with and without hemodialysis.
- Species:
- dog
Plain-English summary
A group of dogs with acute kidney injury (AKI) showed high levels of lipase, an enzyme that can indicate pancreatitis, but only a few were actually diagnosed with that condition. In this study, nearly 29% of the dogs had elevated lipase levels when they were first admitted, and this increased to over 55% during their hospital stay. The severity of kidney injury was linked to higher lipase levels, but treatment with hemodialysis didn't seem to affect these levels. Unfortunately, dogs with more severe kidney issues and high lipase levels had lower chances of survival.
People also search for: dog kidney injury symptoms · high lipase levels in dogs · dog pancreatitis treatment · dog hemodialysis outcome
Abstract
BACKGROUND: Hyperlipasemia has been reported in dogs with acute kidney injury (AKI) but associations with AKI severity, hemodialysis (HD) treatment, and outcome have not been extensively evaluated. OBJECTIVES: Investigate the prevalence and clinical relevance of hyperlipasemia in dogs with AKI, treated with and without HD. ANIMALS: Client-owned dogs (n = 125) with AKI. METHODS: Retrospective data extraction from medical records, including signalment, cause of AKI, duration of hospitalization, survival, plasma creatinine concentration, and 1,2-o-dilauryl-rac-glycero-3-glutaric acid-(6'-methyresorufin) ester (DGGR) lipase activity at admission and throughout hospitalization. RESULTS: A DGGR-lipase activity >3× the upper reference limit (URL) was found in 28.8% and 55.4% of dogs at admission and during hospitalization, respectively, but only 8.8% and 14.9% of dogs, respectively, were diagnosed with acute pancreatitis. Hyperlipasemia >10 × URL was observed in 32.7% of dogs during hospitalization. The DGGR-lipase activity was higher in dogs with International Renal Interest Society (IRIS) Grades 4-5 than Grades 1-3, but correlation between DGGR-lipase activity and creatinine concentration was poor (r = .22; 95% confidence intervals [CI], 0.04-0.38). Treatment with HD was not associated with DGGR-lipase activity independent of IRIS grade. Survival to discharge and 30 days after admission was 65.6% and 59.6%, respectively. High IRIS grades (P = .03) and high DGGR-lipase activity at admission (P = .02) and during hospitalization (P = .003) were associated with nonsurvival. CONCLUSIONS AND CLINICAL IMPORTANCE: Hyperlipasemia is frequent and often marked in dogs with AKI despite only a minority being diagnosed with pancreatitis. Hyperlipasemia is associated with AKI severity but not independently with HD treatment. High IRIS grade and hyperlipasemia were associated with nonsurvival.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37013632/