Peer-reviewed veterinary case report
Hypersensitivity reactions to L-asparaginase in dogs with lymphoma
By Blake, Mary Kay et al.·Published in The Canadian veterinary journal = La revue veterinaire canadienne·2016·VCA West Coast Specialty and Emergency Animal Hospital, United States·View original on PubMed →
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Original publication title: Hypersensitivity reactions associated with L-asparaginase administration in 142 dogs and 68 cats with lymphoid malignancies: 2007-2012.
- Species:
- dog
Plain-English summary
A group of 142 dogs with lymphoid cancers received a chemotherapy drug called L-asparaginase, and 6 of them had hypersensitivity reactions, which can include symptoms like swelling, itching, or difficulty breathing. This reaction occurred in about 4.2% of the dogs treated, but none of the 68 cats given the same drug experienced any reactions. The study suggests that while hypersensitivity reactions can happen, they are relatively rare in dogs and cats, even when they receive multiple doses of the medication. Most dogs tolerated the treatment well without any significant issues.
People also search for: dog chemotherapy side effects · L-asparaginase reactions in dogs · cat cancer treatment safety
Abstract
Clinically significant hypersensitivity reactions (HSRs) to the chemotherapy drug L-asparaginase are reported in humans and dogs, but frequency in small animals is not well-defined. This study retrospectively evaluated the frequency of HSR to L-asparaginase given by IM injection to dogs and cats with lymphoid malignancies. The medical records of all dogs and cats treated with at least 1 dose of L-asparaginase chemotherapy over a 5-year period were reviewed. A total of 370 doses of L-asparaginase were administered to the dogs, with 88 of 142 dogs receiving multiple doses, and 6 dogs experiencing an HSR. A total of 197 doses were administered to the cats, with 33 of 68 cats receiving multiple doses, and no cats experiencing an HSR. Hypersensitivity reactions were documented in 4.2% of dogs, and in association with 1.6% of L-asparaginase doses administered. These results show that HSRs occur uncommonly among dogs and cats, even with repeated dosing.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/26834270/