Ibuprofen toxicosis

Abstract

Ibuprofen is commonly ingested by animals, particularly dogs. Toxicosis may also occur in cats (although few cases are reported), while ferrets are at particular risk due to their small size. Although previously used clinically in dogs, ibuprofen has a narrow margin of safety and causes gastrointestinal signs that can vary from irritation to haemorrhage and perforation. Renal injury may also occur, but liver impairment is rare. Rapid onset neurological signs may occur after ingestion of a large dose. Animals with dehydration, hypotension or pre-existing renal impairment are more at risk of toxicosis. The aim of treatment is prevention and management of gastrointestinal and renal signs. The outcome is usually favourable.